Negative pressure wound therapy (NPWT) is increasingly being used to treat difficult to heal wounds. Chronic wounds are defined as wounds that fail to proceed through a normal reparative process over a three-month period of time. Infection and bacterial bio-burden represent a major challenge in accelerating the rate of healing for both chronic and acute wounds. The IHT systems approach to wound healing eliminates the local factors that contribute to poor wound healing through a sequential, continuous and synergistic use of wound care therapies. The IHT system is safe and effective. When used together, IHT’s products disrupt and eradicate biofilm, bind to and remove pathogens from the wound site without the use of chemicals, and remove exudate by applying negative pressure. Negative pressure accelerates wound healing by initiating a cascade of localized responses, the effectiveness of which is related to the use of an appropriate wound filler in combination with a safe biocidal wound wash.